How Do GLP-1 Medications Work? A Surgeon and Dietitian Answer Your Biggest Questions - Video

How do GLP-1 medications actually work? What results are realistic? Who should take them, and who shouldn't? If you're a woman over 40 dealing with weight that won't budge no matter what you do, or anyone researching semaglutide or tirzepatide, this is the honest clinical conversation most people never get.

Dr. William Yi, MD (board-certified bariatric surgeon) and Kristin Kirkpatrick,
MS, RD (registered dietitian), both OrderlyMeds Expert Advisors, cover how
GLP-1s work, realistic weight loss timelines, side effect management, nutrition, menopause, what to expect emotionally in the first 4-6 weeks, and what happens when you stop.

CHAPTERS
0:00 What Are GLP-1 Medications? How They Work for Weight Loss
2:27 Are GLP-1s Safe? 30+ Years of Research Explained
3:59 How Much Weight Can You Lose on GLP-1s? Realistic Results
6:29 GLP-1 Side Effects: Nausea, Constipation and What to Expect
13:33 What to Eat on GLP-1s: Protein, Fiber and Supplements
30:02 Who Should Take GLP-1s? Candidacy and Contraindications
38:20 Will You Gain Weight Back After Stopping GLP-1s?
41:05 Real Patient Experience: 25 lbs in 6 Months

KEY FACTS FROM THIS WEBINAR
- Semaglutide: ~17.4% average total body weight loss (clinical research)
- Tirzepatide: ~22.5% average total body weight loss
- Nausea affects ~44-50% of patients, typically resolves by week 5
- 30+ years of clinical research behind GLP-1 medications
- The WHO updated its guidelines in 2025 to recognize GLP-1s as a
legitimate obesity treatment
- Roughly 99% of one expert's female GLP-1 patients are peri or
postmenopausal
- Protein target: 0.8 to 1.1g per kg body weight to protect muscle

FREQUENTLY ASKED QUESTIONS
Q: How do GLP-1 medications work for weight loss?
A: They slow digestion, reduce appetite, and help regulate blood sugar.
You eat less because you feel full longer.

Q: How much weight can I expect to lose on a GLP-1?
A: Clinical averages are ~17.4% total body weight loss with semaglutide
and ~22.5% with tirzepatide. Most significant results happen between
months three and six.

Q: What are the most common GLP-1 side effects?
A: Nausea affects about 44-50% of patients, usually resolving by week
five. Constipation and diarrhea are also common. Smaller, more
frequent meals help.

Q: Are GLP-1s a good option for menopause-related weight gain?
A: Yes. Estrogen loss during menopause increases belly fat and insulin
resistance, exactly what GLP-1s are designed to address. Roughly 99%
of one expert dietitian's female GLP-1 patients are peri or
postmenopausal.

Q: What should I eat on a GLP-1?
A: Prioritize protein at every meal (0.8 to 1.1g per kg body weight),
fiber to offset constipation, and healthy fats. Discuss omega-3s,
vitamin D, and B12 with your provider.

Q: Why do I feel irritable and tired in the first weeks on a GLP-1?
A: This is normal and expected. When your body is in a caloric deficit,
it releases cortisol and fights the change. Most patients feel
significantly better after the first 4-6 weeks.

Q: Can GLP-1 medications reduce cravings for alcohol or other substances?
A: Emerging research suggests yes. Some patients report reduced desire
for alcohol, nicotine, and other compulsive behaviors. This is an
active area of clinical research.

Q: Will I gain the weight back when I stop?
A: It depends on the habits you build while on the medication. Patients
who make real dietary and lifestyle changes during treatment often
maintain their results. Those who don't are more likely to regain.

Full guide with side effect tables, nutrition advice, and more:
https://orderlymeds.com/resources/resources-event/how-do-glp-1s-work-for-weight-loss/

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Ready to find out if GLP-1s are right for you? https://orderlymeds.com

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MEDICAL DISCLAIMER
This video is for educational purposes only and is not medical advice. Always consult your healthcare provider before starting or changing any medication or treatment plan.